Protein Modification Reagents
Medchemexpress LLC Bis-mal-lysine-peg4-tfp ester | 1426164-53-5 | 98.0% | C37H45F4N5O13 | 50 MG
Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They consist of two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Consists of two different ligands connected by a linker
- Ligand binds to an E3 ubiquitin ligase
- Ligand binds to the target protein
Medchemexpress LLC Biotin-PEG11-Mal | 1646619-56-8 | 96.5% | C41H71N5O16S | 50 MG
Biotin-PEG11-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Utilizes E3 ubiquitin ligase and target protein ligands
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Boc-N-Amido-PEG4-propargyl | 1219810-90-8 | 99.7% | C16H29NO6 | 100 MG
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs themselves contain two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase, and the other for the target protein, enabling PROTACs to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC DSPE-PEG-Folate, MW 3350 | 1236288-25-7 | 98.2% | C65H114N11O16P | 100 MG
DSPE-PEG-Folate, MW 3350 is a PEG derivative that incorporates folic acid. This compound is designed with a targeting effect, allowing it to bind to folate receptors found in cancer cells. It can form micelles or lipid bilayers, making it suitable for research in targeted drug delivery systems.
- PEG derivative incorporating folic acid
- Targets folate receptors in cancer cells
- Capable of forming micelles or lipid bilayers
- Suitable for targeted drug delivery system research
- Nanoparticles enter cells via FA receptor-mediated endocytosis
- Increases drug elimination half-life
- Prolongs blood circulation time
Medchemexpress LLC Mal-amido-PEG8-TFP ester | 1924596-31-5 | C32H44F4N2O13 | 50 MG
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules composed of two different ligands connected by a linker, where one ligand binds to an E3 ubiquitin ligase and the other to a target protein. These molecules leverage the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Composed of two different ligands connected by a linker
- Binds to an E3 ubiquitin ligase and a target protein
- Leverages the intracellular ubiquitin-proteasome system
- Achieves selective degradation of target proteins
Medchemexpress LLC Apn-c3-peg4-azide | 2183440-32-4 | 97.97% | C24H32N6O6 | 100 MG
APN-C3-PEG4-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group.
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules possessing Alkyne groups.
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Used in PROTAC synthesis for selective degradation of target proteins.
Medchemexpress LLC Biotin-PEG4-amino-t-Bu-DADPS-C6-azide | 1260247-50-4 | 95.0% | C43H67N7O9SSi | 10MG
Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEG-based PROTAC linker and click-chemistry reagent that combines a biotin affinity handle with a terminal azide and a DADPS cleavable linker. It is supplied as a purified research reagent (listed purity 95%) in small pack sizes for synthesis, labeling, and affinity-capture workflows.
- Contains a biotin moiety for affinity enrichment and pull-downs.
- Terminal azide enables copper-catalyzed azide-alkyne cycloaddition for conjugation.
- DADPS cleavable linker allows controlled release after enrichment.
- PEG4 spacer improves solubility and reduces steric hindrance.
- High purity supports reliable conjugation and analytical workflows.
- Small pack sizes suitable for method development and synthesis.
Medchemexpress LLC DSPE-PEG2000-Maleimide | 474922-22-0 | 99.58% | (C2H4O)x-C53H95NO14PNa | 100 MG
DSPE-PEG2000-Maleimide is a phospholipid-PEG conjugate that utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. It covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. It is for research use only and not sold to patients.
- Utilizes DSPE amphiphilicity for lipid bilayer insertion
- Covalently couples to sulfhydryl (-SH) of ligands
- Enables targeting capabilities for particles
- Used in research for breast cancer, lymphoma, and inherited retinal degeneration
- Used to prepare targeted liposomes (TLPD)
Medchemexpress LLC Methyltetrazine-PEG5-alkyne | 1802907-97-6 | 98.0% | C20H26N4O5 | 50 MG
Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). PROTACs are designed to harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This compound is provided as a pink to red solid with high purity, making it suitable for various research applications.
Key features and benefits:
- PEG-based PROTAC linker
- Used for the synthesis of PROTACs
- Supports selective degradation of target proteins
- High purity of 98.0%
- Good solubility in DMSO (≥ 100 mg/mL)
- Stable when stored at 4°C under nitrogen
- Extended stability in solvent at -80°C for 6 months, or -20°C for 1 month (under nitrogen)
Medchemexpress LLC Bromoacetamido-PEG5-DOTA | 2353410-19-0 | 98.0% | C30H55BrN6O13 | 1 MG
Bromoacetamido-PEG5-DOTA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only and not sold to patients.
- Molecular weight: 787.69
- Formula: C30H55BrN6O13
- Cas no.: 2353410-19-0
- Appearance: Oil
- Color: White to off-white
- Purity: 98.02%
Medchemexpress LLC 3,6,9,15,18,21-Hexaoxa-12-azatricosane-1,23-diol | 63721-14-2 | 98.0% | C16H35NO8 | 500 MG
NH-bis-PEG4 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These compounds employ the intracellular ubiquitin-proteasome system to specifically degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Leverages the ubiquitin-proteasome system
- Specifically degrades target proteins
Medchemexpress LLC T-Boc-N-amido-PEG15-Br | 3012589-40-8 | 98.0% | C37H74BrNO17 | 25 MG
t-Boc-N-amido-PEG15-Br is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Hydroxy-PEG4-CH2COOH | 70678-95-4 | ≥97.0% | C10H20O7 | 500 MG
Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase, and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Mal-amido-PEG8-TFP ester | 1924596-31-5 | C32H44F4N2O13 | 25 MG
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. This product leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC DBCO-PEG4-PFP ester | 95.0% | C36H35F5N2O8 | 25 MG
DBCO-PEG4-PFP ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, incorporating a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs are composed of two ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other the protein of interest. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Used in protac synthesis
- Functions as a click chemistry reagent
- Incorporates a dbco group
- Undergoes strain-promoted alkyne-azide cycloaddition (spaac) with azide groups
- Leverages the ubiquitin-proteasome system
- Selectively degrades target proteins